The common variant rs11646213 is associated with preeclampsia in Han Chinese women.

The common variant rs11646213 is associated with preeclampsia in Han Chinese women.

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BACKGROUND: Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors.A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213.This study evaluated the association between preeclampsia and rs11646213.METHODS: A total of 454 cases and 460 controls were recruited to participate in this study.

The single nucleotide polymorphism (SNP) rs11646213 was genotyped by polymerase chain reaction (PCR) and direct sequencing.RESULTS: The allele frequency of rs11646213 was chainsaw file significantly different between the preeclampsia and control groups (P = 0.017, OR = 1.36, 95% CI = 1.

06-1.76).Differences were particularly significant in the severe preeclampsia subgroup (P = 0.002, OR = 1.

54, 95% CI = 1.17-2.03) and fp9550bk the early-onset preeclampsia subgroup (P = 0.004, OR = 1.

57, 95% CI = 1.16-2.13).Genotyping analysis showed that the T allele of rs11646213 could confer a risk for preeclampsia, severe preeclampsia and early-onset preeclampsia.

CONCLUSIONS: Rs11646213 upstream of the CDH13 gene is associated with preeclampsia in Han Chinese women.